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KMID : 1037120220400010030
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The World Journal of Men′s Health
2022 Volume.40 No. 1 p.30 ~ p.37
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Sperm DNA Fragmentation: A Critical Assessment of Clinical Practice Guidelines
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Agarwal Ashok
Farkouh Ala’a
Parekh Neel
Zini Armand
Arafa Mohamed
Kandil Hussein
Tadros Nick
Busetto Gian Maria
Ambar Rafael F.
Parekattil Sijo J.
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Abstract
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Sperm DNA fragmentation (SDF) is implicated in male infertility and adverse reproductive outcomes. With the publication of many studies regarding the etiologies and contributors to SDF, as well as the effects of SDF, guidelines are necessary to aid clinicians in the application of SDF for male fertility evaluation. Two recent clinical practice guidelines were published by Agarwal et al and Esteves et al. In this article, we have evaluated and compared both guidelines. We have found fairly similar recommendations between the two guidelines and have also highlighted the differences between them. Finally, we have summarized and combined the best practice recommendations from both guidelines.
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KEYWORD
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DNA fragmentation, Male infertility, Oxidative stress, Practice guidelines as topic, Reproductive techniques, assisted
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